Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase.
نویسندگان
چکیده
Site directed mutations of the C-methyltransferase domain of squalestatin tetraketide synthase were made in an attempt to alter the methylation pattern of the synthase expressed in vivo: mutation resulted in either no effect or in complete abrogation of polyketide production.
منابع مشابه
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ورودعنوان ژورنال:
- Molecular bioSystems
دوره 6 4 شماره
صفحات -
تاریخ انتشار 2010